Status: Getting worse

Getting worse

Most Recent Data:
11.4 deaths per 100,000 population (2019) *

8.9 per 100,000 *

Desired Direction:
Decrease desired

9.9 deaths per 100,000 population were caused by an overdose involving synthetic opioids other than methadone in 2018  *

Age adjusted to the year 2000 standard population.

Reduce overdose deaths involving synthetic opioids other than methadone (e.g., fentanyl)

Target-Setting Method
Percent improvement


In the past few years, deaths involving fentanyl and other non-methadone synthetic opioids have increased dramatically — and they now make up a large percentage of drug overdose deaths. Interventions to change health care providers’ opioid prescribing behaviors can help reduce opioid-related deaths. Distributing naloxone to reverse overdoses and providing access to medications for opioid use disorder can also help reduce overdose deaths.