Status: Baseline only

Baseline only

Most Recent Data:
0.93 deaths per 100,000 population (2018)

0.84 per 100,000

Desired Direction:
Decrease desired

0.93 deaths per 100,000 population were caused by an overdose involving methadone in 2018 (age adjusted to the year 2000 standard population)

Reduce overdose deaths involving methadone

Target-Setting Method
Percent improvement


Methadone is a synthetic opioid used to address pain and treat people with opioid use disorder. Deaths involving methadone have decreased in recent years, but thousands of people still die from methadone overdoses each year. Interventions to change health care providers’ opioid prescribing behaviors can help reduce methadone-related deaths. Distributing naloxone to reverse overdoses and providing access to medications for opioid use disorder can also help reduce overdose deaths.