About this resource:
Source: The Cochrane Collaborative
Last Reviewed: December 2010
Workgroups: Substance Use Workgroup
In this Cochrane systematic review, the Cochrane Collaborative found that the opioid antagonist naltrexone can help people with alcohol dependence drink less alcohol and drink less often. While naltrexone does not cause serious side effects, it can cause problems like nausea, stomach pain, loss of appetite, and sleepiness. Researchers found that there’s not enough evidence to determine if injectable naltrexone or the opioid antagonist nalmefene is effective in treating alcohol dependence.
Objectives related to this resource (1)
Rösner, S., Hackl‐Herrwerth, A., Leucht, S., Vecchi, S., Srisurapanont, M. & Soyka, M. (2010). Opioid antagonists for alcohol dependence. Cochrane Database of Systematic Reviews, 2010 (12). DOI: 10.1002/14651858.CD001867.pub3.