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Systematic Review

Source: The Cochrane Collaborative

Last Reviewed: December 2010

In this Cochrane systematic review, the Cochrane Collaborative found that the opioid antagonist naltrexone can help people with alcohol dependence drink less alcohol and drink less often. While naltrexone does not cause serious side effects, it can cause problems like nausea, stomach pain, loss of appetite, and sleepiness. Researchers found that there’s not enough evidence to determine if injectable naltrexone or the opioid antagonist nalmefene is effective in treating alcohol dependence.

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Suggested Citation


Rösner, S., Hackl‐Herrwerth, A., Leucht, S., Vecchi, S., Srisurapanont, M. & Soyka, M. (2010). Opioid antagonists for alcohol dependence. Cochrane Database of Systematic Reviews, 2010 (12). DOI: 10.1002/14651858.CD001867.pub3.