Genital Herpes Infection: Serologic Screening

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Systematic Review

Source: U.S. Preventive Services Task Force

Last Reviewed: February 2023

The U.S. Preventive Services Task Force (USPSTF) recommends against routine serologic screening for genital herpes simplex virus (HSV) infection in the general population. This recommendation applies to all adolescents and adults (including pregnant women) who don’t have a known history, signs, or symptoms of HSV. USPSTF found that screening is limited by the low predictive value of the widely available serologic screening tests and the expected high rate of false-positive results that is likely to happen with routine screening of asymptomatic people.

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U.S. Preventive Services Task Force. (2023). Genital Herpes Infection: Serologic Screening. Retrieved from