Gamma_Hydroxybutyrate (GHB) for Treatment of Alcohol Withdrawal and Prevention of Relapses

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Systematic Review

Source: The Cochrane Collaborative

Last Reviewed: February 2010

In this Cochrane systematic review, the Cochrane Collaborative found that gamma‐hydroxybutyric acid (GHB) appears to be more effective than naltrexone and disulfiram for preventing relapse in people with alcohol dependence. Researchers also found insufficient evidence to determine whether GHB is more effective than placebo for treating alcohol withdrawal syndrome or preventing relapses. They found no strong differences between GHB and benzodiazepines or clomethiazole. Researchers concluded that findings about GHB should be weighed along with concerns about the risks of addiction and misuse.

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Suggested Citation


Leone, M.A., Vigna-Taglianti, F., Avanzi, G., Brambilla, R. & Faggiano, F. (2010). Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses. Cochrane Database of Systematic Reviews, 2010 (2).DOI: 10.1002/14651858.CD006266.pub2.