When reviewing questions and supporting evidence at the public meeting, the Committee will refer to studies in the scientific literature. These questions and citations are part of the Committee’s deliberative process and are considered draft material under consideration. The information provided here relates to the topics discussed at this meeting and do not represent all of the questions or literature the Committee may consider as it completes its work. Final questions, details of the literature searches, and final literature that contributed to the Committee’s conclusions will be available in the Committee’s final report and/or on www.DietaryGuidelines.gov and www.NEL.gov.

Saturated Fat Working Group

What is the relationship between saturated fat intake and risk of cardiovascular disease?

Existing Reports

  1. National Heart, Lung, and Blood Institute. Lifestyle interventions to reduce cardiovascular risk: Systematic evidence review from the Lifestyle Work Group, 2013. Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, 2013. http://www.nhlbi.nih.gov/health-pro/guidelines/in-develop/cardiovascular-risk-reduction/lifestyle/index.htm.
  2. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 2014;160(6):398-406. PMID: 24723079. http://www.ncbi.nlm.nih.gov/pubmed/24723079.
  3. Farvid MS, Ding M, Pan A, Sun Q, Chiuve SE, Steffen LM, Willett WC, Hu FB. Dietary linoleic acid and risk of coronary heart disease: A systematic review and meta-analysis of prospective cohort studies. Circulation. 2014 Aug 26. pii: CIRCULATIONAHA.114.010236. [Epub ahead of print] PubMed PMID: 25161045. http://www.ncbi.nlm.nih.gov/pubmed/25161045.
  4. Hooper L, Summerbell CD, Thompson R, Sills D, Roberts FG, Moore HJ, et al. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database Syst Rev. 2012;5:CD002137. PMID: 22592684. http://www.ncbi.nlm.nih.gov/pubmed/22592684.
  5. Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr. 2009 May;89(5):1425-32. doi: 10.3945/ajcn.2008.27124. Epub 2009 Feb 11. PubMed PMID: 19211817; PubMed Central PMCID: PMC2676998. http://www.ncbi.nlm.nih.gov/pubmed/19211817.
  6. Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010;7(3):e1000252. PMID: 20351774. http://www.ncbi.nlm.nih.gov/pubmed/20351774.
  7. Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010;91(3):535-46. PMID: 20071648. http://www.ncbi.nlm.nih.gov/pubmed/20071648.
  8. Skeaff CM, Miller J. Dietary fat and coronary heart disease: summary of evidence from prospective cohort and randomised controlled trials. Ann Nutr Metab. 2009;55(1-3):173-201. doi: 10.1159/000229002. Epub 2009 Sep 15. PubMed PMID: 19752542. http://www.ncbi.nlm.nih.gov/pubmed/19752542.