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PART D: SCIENCE BASE

Table D5-1. Dietary Fiber Intake and Coronary Heart Disease (CHD): Prospective Cohort Studies

(The first 3 citations were used to establish AI for fiber in DRI Macronutrient report.)

Reference Study Design Quintile Relative Risk for All or Fatal CHD Dietary Fiber Intake (g/d) Energy Intake (kcal/d) Dietary Fiber Grams/1000 kcal
Pietinen et al., 1996 21,930 Finnish men, 50–69 y 6-y followup 1
2
3
4
5
1.00
0.87
0.78
0.67
0.68
P<0.001
16.1
20.7
24.3
28.3
34.8
2,722
2,787
2,781
2,754
2,705
5.9
7.4
8.7
10.3
12.9
Rimm et al., 1996 43,757 U.S. men, 40–75 y 6-y followup 1
2
3
4
5
1.00
0.97
0.91
0.87
0.59
P<0.001
12.4
16.6
19.6
23.0
28.9
2,000a
2,000
2,000
2,000
2,000
6.2
8.3
9.8
11.5
14.45
Wolk et al., 1999 68,782 U.S. women, 37–64y, 10-y followup 1
2
3
4
5
1.00
0.98
0.92
0.87
0.77
P=0.07
11.5
14.3
16.4
18.8
22.9
1,600a
1,600
1,600
1,600
1,600
7.2
8.9
10.25
11.75
14.31
Liu, et al., 2002 39.876 U.S. women, 45-75 y; Women’s Health Study 6-y followup 1
2
3
4
5
1.00
0.71
0.72
0.64
0.65
P=0.001
12.5
15.7
18.2
21.1
26.3
1,707
1,742
1,752
1,734
1,694
7.32
9.13
10.39
12.10
15.52
Bazzano, et al., 2003 9,776 U.S. adults, NHANES 19-y followup 1
2
3
4
(quartiles)
1.00
01.01
0.91
0.88
P=0.05
5.8
10.0
13.1
22.2
1,794
1,836
1,713
1,596
3.23
5.44
7.64
13.90
Mozaffarian, et al., 2003 3,588 U.S. men and women, ≥ 65 y; 10-y followup 1
2
3
4
5
1.00
0.95
0.90
0.92
0.77
P=0.3
<9.7b
9.7-13.2
13.5-17.6
17.9-23.0
>23.0
1,820a
1,820
1,820
1,820
1,820
<5.32
5.32-7.25
7.41-9.67
9.84-1264
>12.64

aDietary fiber intake is adjusted to caloric intake.

bTotal dietary fiber derived by adding values for cereal, vegetable and fruit fiber.

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