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PART D: SCIENCE BASE

Table D2-4. Decreased Fat Intake and Body Weight Change in Nonobese or Moderately Obese Subjects [IOM Table 11.1 (IOM, 2002)]

Reference Study Design Dietary Fat (percent of energy) Weight Change (kg) Comments
Short-term studies (< 1 year)
Boyar et al., 1988 19 women
6 mo-intervention
Ad libitum diet
34→21 –5.1 Decreased fat intake associated with decreased energy intake
Buzzard et al., 1990 29 postmenopausal women
3-mo parallel
Ad libitum diet
38→23
39→35
–2.8
–1.3
Decreased fat intake associated with decreased energy intake
Bloemberg et al., 1991 80 men
26-wk parallel
Ad libitum diet
39→34
38→37
–0.94
+0.06
 
Kendall et al., 1991 13 women
11-wk crossover
Controlled diet
20→25
35→40
–2.54
–1.26
Decreased fat intake associated with decreased energy intake
Low-fat diet hypocaloric
Leibel et al., 1992 13 men and women
15- to 56-d intervention
Controlled diet
0, 40, or 70 No significant changes in body weight Isocaloric diets
Westerterp et al., 1996 217 men and women
6-mo parallel
Ad libitum diet
35→33
36→41
+0.3
+1.1
 
Raben et al., 1997 11 women
14-d crossover
Ad libitum
46→28 –0.7 Decreased fat intake associated with decreased energy intake
Gerhard et al., 2000 22 women
4-wk crossover
Controlled diet
20
40
–1.1
–0.3
Low-fat diet hypocaloric
Saris et al., 2000 398 men and women
6-mo parallel
Ad libitum diet
36→26
36→28
36→37
–0.9
–1.8
+0.8
Decreased fat intake associated with decreased energy intake
Long-term studies (1 year)
Lee-Han et al., 1988 57 women
1-year parallel
Ad libitum diet
36→23→26
36→34→36
6 mo
–1.16
+0.07
12 mo
–0.93
+0.62
Decreased fat intake associated with decreased energy intake
Boyd et al., 1990 206 women
1-year parallel
Ad libitum diet
37→21
37→35
–1.0
0
 
Sheppard et al., 1991 276 women
1- and 2-year parallel
Ad libitum diet
0 to 1 y
39→22
39→37

1 to 2 y
22→23

–3.0
–0.4


+1.1
Decreased fat intake associated with decreased energy intake
Baer, 1993 70 men
1-year parallel
Ad libitum diet
38→31
37→36
–5.0
+1.0
Decreased fat intake associated with decreased energy intake
Kasim et al., 1993 72 women
1-year parallel
Ad libitum diet
36→18
36→34
–3.4
–0.8
Decreased fat intake associated with decreased energy intake
Black et al., 1994 76 men and women
2-year parallel
Ad libitum diet
40→21
39→39
–2.0
–1.0
 
Knopp et al., 1997 137 men
1-year parallel
Ad libitum diet
36→27
35→22
–2.9
–2.9
 
Stefanick et al., 1998 177 postmenopausal women and 190 men
1-year parallel
Ad libitum diet
Women
23
28
Men
22
30
Women
–2.7
+0.8
Men
–2.8
+0.5
Decreased fat intake associated with decreased energy intake
Kasim-Karakas et al., 2000 54 postmenopausal women
1-year intervention
Controlled diet 4 mo
Ad libitum diet 8 mo
34→14→12 4 mo
–1.3
12 mo
–5.9
 

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